CVE-2025-70560: Boltz contains an insecure deserialization vulnerability in its molecule loading functionality

February 3, 2026 (updated February 4, 2026)

Boltz 2.0.0 contains an insecure deserialization vulnerability in its molecule loading functionality. The application uses Python pickle to deserialize molecule data files without validation. An attacker with the ability to place a malicious pickle file in a directory processed by boltz can achieve arbitrary code execution when the file is loaded.

References

github.com/advisories/GHSA-fjm6-8xp2-4fwc
github.com/jwohlwend/boltz
github.com/jwohlwend/boltz/blob/cb04aeccdd480fd4db707f0bbafde538397fa2ac/src/boltz/data/mol.py
github.com/jwohlwend/boltz/issues/600
nvd.nist.gov/vuln/detail/CVE-2025-70560

Code Behaviors & Features

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